Algunos de nuestros estudios están publicados en revistas o actas de congresos sujetos a normas de copyright, por lo que sólo será posible el uso de este material como copia personal. Los investigadores interesados pueden solicitar una copia personal a través de este contacto.


  • Priego-Torres, B. M., Sanchez-Morillo, D., Fernandez-Granero, M. A., & Garcia-Rojo, M. (2020). Automatic segmentation of whole-slide H&E stained breast histopathology images using a deep convolutional neural network architecture. Expert Systems with Applications, 113387. Factor de Impacto JCR 4.292. Décil D1, Cuartil Q1.
  • Sanchez-Morillo, D., Muñoz-Zara, P., Lara-Doña, A., & Leon-Jimenez, A. (2020). Automated Home Oxygen Delivery for Patients with COPD and Respiratory Failure: A New Approach. Sensors, 20(4), 1178. Factor de impacto JCR 3.031. Cuartil Q1.
  • Bueno, G., Gonzalez-Lopez, L., Garcia-Rojo, M., Laurinavicius, A., & Deniz, O. (2020). Data for glomeruli characterization in histopathological images. Data in brief, 29, 105314. Citescore 0.93.
  • López, C., Bosch, R., Orero, G., Korzynska, A., García-Rojo, M., Bueno, G., … & Fontoura, L. (2020). The Immune Response in Nonmetastatic Axillary Lymph Nodes Is Associated with the Presence of Axillary Metastasis and Breast Cancer Patient Outcome. American Journal of Pathology, 190(3), 660-673. Factor de Impacto JCR 3.762. Cuartil Q1.


  • Priego, B., & Duro, R. J. (2019). An approach for the customized high-dimensional segmentation of remote sensing hyperspectral images. Sensors, 19(13), 2887. Factor de Impacto JCR 3.031. Cuartil Q1.
  • García Rojo M (2019). Artificial intelligence in Pathological Anatomy. Revista Española de Patología  52(4), 205-207.
    Gibert-Ramos, A., López, C., Bosch, R., Fontoura, L., Bueno, G., García-Rojo, M., … & Lejeune, M. (2019). Immune response profile of primary tumour, sentinel and non-sentinel axillary lymph nodes related to metastasis in breast cancer: an immunohistochemical point of view. Histochemistry and cell biology, 1-17. Factor de Impacto JCR 2.64. Cuartil Q2.
  • Antonio Leon Jimenez, M Pérez Morales, Alejandro Lara Doña, MA Fernández Granero, Daniel Sánchez Morillo (2019). A novel intelligent portable home oxygen therapy unit for patients with chronic respiratory failure. European Respiratory Journal 2019; 54: Suppl. 63, PA3966.  DOI: 10.1183/13993003.congress-2019.PA3966.
  • Lara-Doña A., Sanchez-Morillo D., Pérez-Morales M., Fernandez-Granero M.Á., Leon-Jimenez A. (2019). A Prototype of Intelligent Portable Oxygen Concentrator for Patients with COPD Under Oxygen. In: Henriques J., Neves N., de Carvalho P. (eds) XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019. MEDICON 2019. IFMBE Proceedings, vol 76. Springer, Cham DOI: 10.1007/978-3-030-31635-8_55
  • Modelo de Utilidad. Dispositivo de dosificación automática de flujo para equipos de oxigenoterapia. Daniel Sánchez, Antonio León Jiménez, Miguel Ángel Fernández Granero, Luis Felipe Crespo Foix. U201831680, 2019.
  • García, Marcial; De Mena, David; Muriel, Pedro; Domínguez, Manuel; Bueno, Gloria (2019). New European Union Regulations Related to Whole Slide Image Scanners and Image Analysis Software  Journal of Pathology Informatics 10(29


  • Priego, B., Prieto, A., Duro, R. J., & Chanussot, J. (2018). A cellular automata‐based filtering approach to multi‐temporal image denoising. Expert Systems, 35(2), e12235. Factor de impacto JCR 1.505. Cuartil Q2.
  • Fernandez-Granero, M. A., Sanchez-Morillo, D., & Leon-Jimenez, A. (2018). An artificial intelligence approach to early predict symptom-based exacerbations of COPD. Biotechnology & Biotechnological Equipment, 32(3), 778-784. Factor de Impacto JCR 1.227. Cuartil Q3.
  • Clunie D, Hosseinzadeh D, Wintell M, De Mena D, Lajara N, Garcia‑Rojo M, et al. Digital Imaging and Communications in Medicine Whole Slide Imaging Connectathon at Digital Pathology Association Pathology Visions 2017. J Pathol Inform 2018;9:6.
  • Guadalajara, M., Hernández González, A., Carrasco García de León, S., Rojo, M. G., & Del Real Francia, M. (2018). Mycotic Cerebral Aneurysms Secondary to Scedosporium Prolificans Infection in a Patient with Multiple Sclerosis. Journal of Clinical Neurology, 14(4), 601-603. Factor de impacto JCR 2.851. Cuartil Q2.
  • Fraggetta, F; Yagi, Y; García, Marcial; Pantanowitz, L (2018). The Importance of eSlide Macro Images for Primary Diagnosis with Whole Slide Imaging. Journal of Pathology Informatics 9(46).


  • Priego, B., Duro, R. J., & Chanussot, J. (2017). 4DCAF: A temporal approach for denoising hyperspectral image sequences. Pattern Recognition, 72, 433-445. Factor de impacto JCR 3.962. Cuartil Q1.
  • Fernandez-Granero, M. A., Sarmiento, A., Sanchez-Morillo, D., Jiménez, S., Alemany, P., & Fondón, I. (2017). Automatic CDR estimation for early glaucoma diagnosis. Journal of healthcare engineering, Factor de impacto JCR 1.261. Cuartil Q4.
  • Sanchez-Morillo, D., Olaby, O., Fernandez-Granero, M. A., & Leon-Jimenez, A. (2017). Physiological closed-loop control in intelligent oxygen therapy: a review. Computer methods and programs in biomedicine, 146, 101-108. Factor de Impacto JCR 2.674. Cuartil Q1.
  • Miguel Angel Fernandez-Granero, Auxiliadora Sarmiento Vega, Anabel Isabel García, Daniel Sanchez-Morillo, Soledad Jiménez, Pedro Alemany, Irene Fondón (2017). Automatic Tool for Optic Disc and Cup Detection on Retinal Fundus Images. International Work-Conference on Artificial Neural Networks, 246-256.
  • Ramos‐Rodríguez, C., M. García‐Rojo, G. Romero‐Aguilera, M. García‐Arpa, L. González‐López, M. P. Sánchez‐Caminero, J. González‐García et al (2017). Epidemiologic, clinical and demographic features of primary cutaneous lymphomas in Castilla‐La Mancha, Spain: Are we different? Journal of the European Academy of Dermatology and Venereology 32 (5): e168-e171.
  • D Sanchez-Morillo, O Olaby, MA Fernandez-Granero, A Leon-Jimenez (2017).Automatic Recognition of Daily Physical Activities for an Intelligent-Portable Oxygen Concentrator (iPOC). International Work-Conference on Artificial Neural Networks, 212-221.
  • Mayayo E, García Rojo M, Félix Conde A.(2017). Eureka!  Rev Esp Patol. 51(1):1-2. Teaching Digital Pathology: The International School of Digital Pathology and Proposed Syllabus Mea VD, Carbone A, Di Loreto C, Bueno G, De Paoli P, García-Rojo M, de Mena D, Gloghini A, Ilyas M, Laurinavicius A, Rasmusson A, Milione M, Dolcetti R, Pagani M, Stoppini A, Sulfaro S, Bartolo M, Mazzon E, Soyer HP, Pantanowitz L. J Pathol Inform. 25;8:27.
  • Fernández-Carrobles, M. M., Bueno, G., García-Rojo, M., González-López, L., López, C., & Déniz, O. (2017). Automatic quantification of IHC stain in breast TMA using colour analysis. Computerized Medical Imaging and Graphics, 61, 14-27. Factor de impacto JCR 2.674. Cuartil Q1.
  • Henares-Molina, A., Benzekry, S., Lara, P. C., García-Rojo, M., Pérez-García, V. M., & Martínez-González, A. (2017). Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas. PloS one, 12(6). Factor de impacto JCR 2.766. Cuartil Q1.
  • Pérez‐Ortiz, J. M., Galiana‐Simal, A., Salas, E., González‐Martín, C., García‐Rojo, M., & Alguacil, L. F. (2017). A high‐fat diet combined with food deprivation increases food seeking and the expression of candidate biomarkers of addiction. Addiction biology, 22(4), 1002-1009. Factor de impacto JCR 5.578. Cuartil Q1.
  • López-Fandino, J., Priego, B., Heras, D. B., & Argüello, F. (2017). GPU projection of ECAS-II segmenter for hyperspectral images based on cellular automata. IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 10(1), 20-28. Factor de Impacto JCR 2.913. Cuartil Q1.


  • Sanchez-Morillo, D., Fernandez-Granero, M. A., & Leon-Jimenez, A. (2016). Use of predictive algorithms in-home monitoring of chronic obstructive pulmonary disease and asthma: a systematic review. Chronic respiratory disease, 13(3), 264-283. Factor de Impacto JCR 1.818. Cuartil Q2.
  • García-Rojo M (2016). International Clinical Guidelines for the Adoption of Digital Pathology: A Review of Technical Aspects. Pathobiology. 2016;83(2-3):99-109.
  • García-Rojo M, Ordi J.(2016). Trying to Understand Digital Pathology before We Move to Computational Pathology. Pathobiology. 2016;83(2-3):57-60.
  • Bueno G, Fernández-Carrobles MM, Deniz O, García-Rojo M. (2016). New Trends of Emerging Technologies in Digital Pathology. Pathobiology. 83(2-3):61-9.
  • Tadeo I, Bueno G, Berbegall AP, Fernández-Carrobles MM, Castel V, García-Rojo M, Navarro S, Noguera R. (2016). Vascular patterns provide therapeutic targets in aggressive neuroblastic tumors. Oncotarget. 12;7(15):19935-47. Factor de impacto JCR 5.168. Cuartil Q1.
  • Idoate MA, García-Rojo M. (2016) Clinical Neuropathology Views: Digital networking in European neuropathology: An initiative to facilitate truly interactive consultations.
    Clin Neuropathol. 35(2):53-7.
  • Castellsagué X, Alemany L, Quer M, Halec G, Quirós B, et al. (2016). HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients. ICO International HPV in Head and Neck Cancer Study Group. J Natl Cancer Inst. 108(6):djv403.
  • García-Rojo M.(2016) International Clinical Guidelines for the Adoption of Digital Pathology: A Review of Technical Aspects.  Pathobiology. 83(2-3):99-109.
  • García-Rojo M, Ordi J. (2016) Trying to Understand Digital Pathology before We Move to Computational Pathology Pathobiology. 83(2-3):57-60.
  • Henares-Molina, A., Benzekry, S., Lara, P., García-Rojo, M., Pérez-García, V., & Martínez-González, A. (2016). Optimized radiotherapy protocols delay the malignant transformation of low-grade gliomas in-silico  In 5th Quadrennial Meeting of the World Federation of Neuro-Oncology Societies (Vol. 19, No. suppl_3)


  • Chyu, M. C., Austin, T., Calisir, F., Chanjaplammootil, S., Davis, M. J., Favela, J., … & Hornero, R. (2015). Healthcare engineering defined: a white paper. Journal of healthcare engineering, 6(4), 635-648. Factor de impacto JCR 0.925. Cuartil Q4.
  • Velazquez-Peña, F. D. B., Sanchez-Morillo, D., Crespo-Miguel, M., Astorga-Moreno, S., Santi-Cano, M. J., Fernandez-Granero, M. A., & Leon-Jimenez, A. (2015). Development and Evaluation of an Automated, Home-Based, Electronic Questionnaire for Detecting COPD Exacerbations. Journal of Healthcare Engineering, 6(4), 705-716. Factor de Impacto JCR 0.925. Cuartil Q4.
  • Fernández-Carrobles, M. M., Bueno, G., Déniz, O., Salido, J., García-Rojo, M., & Gonzández-López, L. (2015). Frequential versus spatial colour textons for breast TMA classification. Computerized Medical Imaging and Graphics42, 25-37. Factor de impacto JCR 1.385. Cuartil Q2.
  • D Sánchez-Morillo, M Crespo, A León, LF Crespo Foix (2015). A novel multimodal tool for telemonitoring patients with COPD. Informatics for Health and Social Care 40 (1), 1-22
    2015. Factor de impactoJCR 0.711. Cuartil Q3.
  • Lopez-Gordo, M. A., Sánchez-Morillo, D., & Van Gerven, M. A. (2015). Spreading codes enables the blind estimation of the hemodynamic response with short-events sequences. International journal of neural systems25(01), 1450035. Factor de Impacto JCR 6.085. Cuartil Q1.
  • Fernandez-Granero, M. A., Sanchez-Morillo, D., & Leon-Jimenez, A. (2015). Computerised analysis of telemonitored respiratory sounds for predicting acute exacerbations of COPD. Sensors15(10), 26978-26996. Factor de Impacto JCR 2.033. Cuartil Q1.
  • Sanchez-Morillo, D., Fernandez-Granero, M. A., & Jiménez, A. L. (2015). Detecting COPD exacerbations early using daily telemonitoring of symptoms and k-means clustering: a pilot study. Medical & biological engineering & computing53(5), 441-451. Factor de Impacto JCR 1.797. Cuartil Q2.
  • Fernandez-Granero, M. A., Sanchez-Morillo, D., Lopez-Gordo, M. A., & Leon, A. (2015, June). A machine learning approach to prediction of exacerbations of chronic obstructive pulmonary disease. In International Work-Conference on the Interplay Between Natural and Artificial Computation (pp. 305-311). Springer, Cham.
  • MÁF Granero, DS Morillo, A León, S Astorga, F Crespo (2015). Dispositivo Móvil para la Predicción Domiciliaria de Exacerbaciones de EPOC. Especial: mHealth (Salud móvil), 27.


  • Del Milagro Fernández-Carrobles, M., Bueno, G., Déniz, O., Salido, J., & García-Rojo, M. (2014). Automatic handling of tissue microarray cores in high-dimensional microscopy images. IEEE Journal of Biomedical and Health Informatics18(3), 999-1007. Factor de impacto JCR 1.440. Cuartil Q2.
  • Fernández-Granero, M. A., Sánchez-Morillo, D., León-Jiménez, A., & Crespo, L. F. (2014). Automatic prediction of chronic obstructive pulmonary disease exacerbations through home telemonitoring of symptoms. Bio-medical materials and engineering24(6), 3825-3832. Factor de impacto JCR 1.091. Cuartil Q4.
  • Sánchez-Morillo, D., López-Gordo, M. A., & León, A. (2014). Novel multiclass classification for home-based diagnosis of sleep apnea hypopnea syndrome. Expert systems with applications41(4), 1654-1662. Factor de impacto JCR 2.240. Cuartil Q1.
  • Lopez-Gordo, M. A., Sanchez-Morillo, D., & Valle, F. P. (2014). Dry EEG electrodes. Sensors14(7), 12847-12870. Factor de impacto JCR 2.245. Cuartil Q3.
  • Morillo, D. S., Granero, M. F., León, A., & Crespo, L. F. (2014). Automatic Classification of Respiratory Sounds Phenotypes in COPD Exacerbations. In XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013 (pp. 603-606). Springer, Cham.
  • Granero, M. F., Morillo, D. S., León, A., Gordo, M. L., & Crespo, L. F. (2014). Radial-basis-function based prediction of COPD exacerbations. In XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013 (pp. 1455-1458). Springer, Cham.


  • Priego, B., Souto, D., Bellas, F., & Duro, R. J. (2013). Hyperspectral image segmentation through evolved cellular automata. Pattern Recognition Letters34(14), 1648-1658. Factor de impacto JCR 1.062. Cuartil Q2.
  • Morillo, D. S., Moreno, S. A., Granero, M. Á. F., & Jiménez, A. L. (2013). Computerized analysis of respiratory sounds during COPD exacerbations. Computers in biology and medicine43(7), 914-921. Factor de impacto JCR 1.475. Cuartil Q2.
  • Sánchez Morillo, D., León Jiménez, A., & Moreno, S. A. (2013). Computer-aided diagnosis of pneumonia in patients with chronic obstructive pulmonary disease. Journal of the American Medical Informatics Association20(e1), e111-e117. Factor de impacto JCR 3.932. Cuartil Q1.
  • Sánchez-Morillo, D., Crespo, M., León, A., & Crespo Foix, L. F. (2013). A novel multimodal tool for telemonitoring patients with COPD. Informatics for Health and Social Care40(1), 1-22. Factor de impacto JCR 0.711. Cuartil Q3.
  • Morillo, D. S., & Gross, N. (2013). Probabilistic neural network approach for the detection of SAHS from overnight pulse oximetry. Medical & biological engineering & computing51(3), 305-315. Factor de impacto JCR 1.5. Cuartil Q2.
  • D Sánchez Morillo, LF Crespo Foix, A León Jiménez (2013). AMICA Wearable Sensor System. EU Project Deliverable.


  • Morillo, D. S., Gross, N., León, A., & Crespo, L. F. (2012). Automated frequency domain analysis of oxygen saturation as a screening tool for SAHS. Medical engineering & physics34(7), 946-953. Factor de impacto JCR 1.8. Cuartil Q2.
  • N Groß, DS Morillo, S J. Friedmann, AL Jimenez (2012). Pulsoximetrisches SAHS-Screening – Zuverlässigkeit und Potenziale. Somnologie 11 (16(1)).


  • Leon, A., Astorga, S., Crespo, M., Sanchez, D., Failde, I., & Crespo, F. (2011). Development of an automated questionnaire for the early detection of COPD exacerbations (AQCE).  Respir. J.38(Suppl_55), p562. Factor de impacto JCR 5.895. Cuartil Q1.
  • M Crespo, DS Morillo, LF Crespo, MA Fernandez (2011). Linguistic capabilities in a self-management medical device to improve usability of elderly people. Euromediterranean Scientific Congress on Engineering (EMSCE2011), 860-864 .
  • N Gross, DS Morillo, AL Jimenez, C Kunze, A Rashid. (2011). Exzessive tagesschläfrigkeit: verfahren zur bestimmung schlafstörungsbezogener auslöser.7th Conference of the Labor, Organizational and Economic Psychology.
  • Tom Zentek, N Gross, Ds Morillo, et al. (2011). The role and needs of informal careers of people with chronic conditions. AAL FORUM 2011.
  • Tom Zentek, N Gross, Ds Morillo, et al. (2011). Development and evaluation of service concepts improving life quality of COPD patients and informal caregivers AAL FORUM 2011.
  • Gross, N., Friedmann, J., Kunze, C., Stork, W., Morillo, D. S., Jimenez, A. L., & Foix, L. F. C. (2011, January). Increasing Reliability and Information Content of Pulse Oximetric SAHS Screening Algorithms. In BIOSIGNALS (pp. 438-445).


  • Sánchez Morillo, D., Ojeda, J. L. R., Foix, L. F. C., & Jiménez, A. L. (2010). An accelerometer-based device for sleep apnea screening. IEEE Transactions on Information Technology in Biomedicine14(2), 491–499. Factor de impacto JCR 1.707. Cuartil Q2.
  • Crespo, L. F., Morillo, D. S., Crespo, M., Leon, A., Astorga, S., Giokas, K., & Kouris, I. (2010, November). Telemonitoring in AMICA: A design based on and for COPD. In Proceedings of the 10th IEEE International Conference on Information Technology and Applications in Biomedicine (pp. 1-6). IEEE.
    M Crespo, DS morillo, J Rodriguez, et al. (2010).Development of a linguistic interface for COPD patients in AMICA. Scientific international Engineering Conference (CCII 2010)
  • N Gross,T. Zentek, F Sauter, et al. (2010). Schlafapnoe-screening fur patienten mit chronisch obstruktiver lungenerkrankung COPD. Somnologie schlafforschung und schlafmedizin 14 (1), 52
  • M Crespo, D Sánchez, F Crespo, S Astorga, A León(2010).  Collaborative Dialogue Agent for COPD Self-management in AMICA: A First Insight.  Advances in Practical Applications of Agents and Multiagent Systems, 75-80.


  • Morillo DS, Rojas JL, Crespo LF, León A, Gross N. Poincaré analysis of an overnight arterial oxygen saturation signal applied to the diagnosis of sleep apnea hypopnea syndrome. Physiol Meas. 2009;30(4):405‐ Factor de impacto JCR 1.430. Cuartil Q3.
  • Foix, L. C., Morillo, D. S., Crespo, M., Gross, N., Kunze, C., Giokas, K., & Jimenez, J. A. (2009, November). AMICA telemedicine platform: a design for management of elderly people with COPD. In 2009 9th International Conference on Information Technology and Applications in Biomedicine (pp. 1-4). IEEE.
  • Groß, N., Zentek, T., Kunze, C., Rashid, A., Stork, W., Korb, H., … & Leon, A. (2009). AMICA optimization of the care and treatment management of COPD patients. At GI Annual Meeting (pp. 1198-1212).


  • JL Rojas Ojeda, LF Crespo, Daniel Sánchez y Nicole Gross (2008). Sistema para la determinación y monitorización de los índices de desaturaciones y tasa respiratoria
    instantánea. Patente ES-2302446
  • N Gross, C. Kunze, W. Stork, et al.   (2008) Analyse von atemfrequenz und atmungsregulation anhand pulsoximetrischer messwerte. Workshop Biosignalverarbeitung 2008, s1


  • Morillo, D. S., Ojeda, J. R., Foix, L. C., Rendón, D. B., & Leon, A. (2007, August). Monitoring and analysis of cardio respiratory and snoring signals by using an accelerometer. In 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 3942-3945). IEEE.
  • Rendon, D. B., Ojeda, J. L. R., Foix, L. F. C., Morillo, D. S., & Fernandez, M. A. (2007, August). Mapping the human body for vibrations using an accelerometer. In 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 1671-1674). IEEE.
  • JL Rojas Ojeda, LF Crespo, Daniel Sánchez y Nicole Gross (2007). Sistema para la monitorización y análisis de señales cardiorrespiratorias y del ronquido. Patente ES2298060
  • N Gross, C. Kunze, W. Stork, et al. (2007) Schlafapnoepradiagnose und klassifikation basierend auf nichtlinearer analyse pulsoximeterischer daten. Biomedizinische Technik, 41st Annual Congress (BMT 2007), 52.